Regular, early lifestyle changes key to reducing type 2 diabetes

Regular, early lifestyle changes key to reducing type 2 diabetes

Regular and early one-to-one educational sessions on healthy diet and lifestyle could reduce the risk of developing type 2 diabetes and cardiovascular disease (CVD), a new research published today in BMC Medicine suggests.

Unlike previous studies which have focused on high risk older people, researchers from King’s College London and the Diabetes Association of Sri Lanka looked at almost 4000 people aged between 5 and 40.

The results suggest regular and realistic interventions with high risk younger people – especially if done before 18- may be more successful, and cost-effective than less-intensive and irregular sessions.

Asia is a major site of Type 2 diabetes, accounting for 60 per cent of people with the disease worldwide. South Asians are predisposed to develop the disease early on, with a third of future cases predicted to occur in those aged below 45 years old.

Participants in the study had been screened out of a total of 23,298 people, and identified as being at a higher risk of developing type 2 diabetes and CVD, but not yet diagnosed.

Out of the 4672 participants aged between five and 40 who began the study, 3539 were eligible for analysis after three years.

Participants were randomized into two groups; pragmatic lifestyle modification (P-LSM) program and control lifestyle modification program (C-LSM).

There were no significant differences in age, gender, clinical or biochemical characteristics between the two groups at time of randomization.

Both groups received an identical lifestyle education program, aimed at reducing weight, improving diet, reducing psychological stress and increasing physical activity.

Those in the P-LSM group received one-to-one advice, assessment and education sessions every three months for an average of three years.

Those in C-LSM in comparison received these sessions only once a year for an average of three years. For participants younger than 16 the advice and guidance in both groups was also given to the child’s parents.

The program was delivered by ‘peer educators’, i.e. educators aged between 18 to 40 years old. They were trained by experts from the University of Colombo and the MV diabetes research center in Chennai India with regular refresher sessions.

The groups were monitored throughout the period for several risk factors that lead to cardio-metabolic disease in later life: new type 2 diabetes, hypertension, cardiovascular disease and renal disease.

After three years, the researchers found that overall, these risk factors occurred less in the P-LSM group than in the control group (479 compared to 562), a significant risk reduction of 11%.

New occurrences of hypertension were significantly reduced with those in the P-LSM group (115 participants) versus the control group (152 participants).

The researchers found further reductions in the occurrence of type 2 diabetes between the two groups (58 in the P-LSM group versus 72 in the C-LSM group).

The reduction was especially pronounced in participants aged under 18; when looked at overall, the risk factors occurred less in the P-LSM group versus C-LSM, with 140 versus 174, a 17% risk reduction.

The researchers state that further research is required to establish the longer-term impact of such lifestyle changes in a younger population.

The trial does not explain the mechanisms behind the reductions in risk factors rather establishes associations that require further research.

Additionally, the results in this young urban population may not be generalizable to other groups.