Gastric bypass is surgery that helps you lose weight by changing how your stomach and small intestine handle the food you eat.
Studies have shown that bariatric surgery can lead to reversal of type 2 diabetes in both rodents and humans.
However, this beneficial effect cannot be explained solely by weight loss.
In a new study published in The American Journal of Pathology, researchers investigating gastric bypass in a mouse model of type 2 diabetes confirmed that bypass surgery improves glucose tolerance and insulin sensitivity.
Interestingly, the improved metabolism occurred with changes in gut microorganisms, suggesting a potential role for gut microbiota in diabetes reversal.
“We found that bypass surgery induced gut microbiota changes, which may be the key reason for diabetes reversal after surgery.”
“Our data indicate that suppressed inflammation is the result, not the cause, of diabetes reversal in these genetically modified mice.”
Researchers found that in mice, bypass surgery reversed the metabolic abnormalities indicative of diabetes.
Glucose tolerance and insulin sensitivity were greatly improved, and there was less fat accumulation in liver and white adipose tissue.
Insulin sensitivity reached normal levels within two weeks following surgery and lasted for at least eight weeks.
Six weeks after bypass surgery, oral glucose tolerance in the treated mice was significantly lower than in the diabetic mice.
Examination of the bacteria in the gut before and after bypass surgery showed a decrease in pathogenic bacteria and an increase in beneficial microflora.
Inflammation, especially in white fat tissue and liver, is thought to play an important role in obesity and type 2 diabetes.
Eight weeks after bypass surgery, significant reductions in inflammatory indicators occurred in the liver and fat tissue.